Phil Pharmawealth/Atlantic Sodium Bicarbonate Dosage/Direction for Use

By intravenous injection, from 10 to 150 mL may be given according to the degree of hyponatremia.
For correction of metabolic acidosis the dose depends on the degree of the disorder of the acid-base status.
According to the blood gas values the amount to be administered is calculated according to the following formula: See equation.
# mL of 1 M (8.4% w/v) sodium bicarbonate solution base deficit x kg BW x 0.3
(The factor 0.3 corresponds to the proportion of the extracellular fluid relation to total body fluid).
Example: If in patient of 70 kg BW the base deficit is 5 mmol/L, then 5 x 70 x 0.3 = 105 mL of 8.4% w/v Sodium Bicarbonate Injection are not to be given.
Correction of metabolic acidosis should not be too rapidly. It is advisable to start administering only half of the calculated dose and adjust further doses according to the actual results of the blood gas analysis.
For urine alkalization the dose is adjusted according to the desired pH of the urine and administration should be accompanied by monitoring of the acid-base balance and the water balance. Care should be taken not to exceed the maximum infusion rate stated as follows.
Maximum Daily Dose: According to the correction requirement.
Flow Rate: Up to 1.5 mmol of sodium bicarbonate/kg BW/h, corresponding to 1.5 mL solution/kg BW/h.
Method of Administration: Intravenous Use.
The solution must be administered via a central vein.